Chlorobiocicacid and 3-(carbobenzoxyamino)-4,7-dihydroxy-8-methylcoumarin were identified as two new inhibitors of Micrococcus luteus DNAgyrase.Both compounds possess weak antibacterial activity against whole M. luteus cells which indicates that they probably lack efficient transport functions to penetrate the cell envelope.Coumarin containing antibiotics (including novobiocin, chlorobiocin and coumermycin) exert
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Althaus et al. (1988) studied this question.
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