Key result
HTLV-I positivity is not linked to altered muscle lymphocyte subsets or macrophage proportions in polymyositis.
Why the study?
HTLV-I is associated with polymyositis, but the histological features of HTLV-I-positive polymyositis required clarification.
Are there differences in lymphocyte subsets in muscle biopsies between HTLV-I positive and negative patients with polymyositis?
Observational (n=10)
No
Are there differences in lymphocyte subsets in muscle biopsies between HTLV-I positive and negative patients with polymyositis?
HTLV-I infection does not significantly alter the lymphocyte subset infiltrate in the muscles of patients with polymyositis.
Answers are grounded in this paper and cite their sources.
HTLV-I status does not affect muscle lymphocyte subsets in polymyositis; leaves open whether infection modifies disease course or treatment response.
Recent epidemiologic studies have shown that human T-lymphotropic virus type I (HTLV-I) is associated with polymyositis. To clarify the histological features of HTLV-I positive polymyositis, we studied muscle tissue from two groups of patients with polymyositis, those seropositive for HTLV-I (5 patients) and those seronegative (5 patients). We examined the lymphocyte subsets in muscle biopsies using monoclonal antibodies. In the endomysium, a variable number of T-lymphocytes and macrophages and a smaller proportion of B-lymphocytes were found in both groups. In both HTLV-I positive and negative patients a variable number of T-lymphocytes and macrophages, with a smaller number of B-lymphocytes, were found in the perimysium. As a whole, the T-lymphocytes were predominantly of the helper/inducer phenotype in both groups. We failed to find any specific phenotype distribution among T-cells infiltrating the muscle of HTLV-I carriers with polymyositis.
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Ijichi et al. (1992) conducted an observational in Polymyositis (n=10). HTLV-I seropositivity vs. HTLV-I seronegativity was evaluated on Distribution of lymphocyte subsets and macrophages in muscle biopsies. Lymphocyte subsets and the proportion of macrophages in muscle tissue of polymyositis patients were similar between HTLV-I positive and negative groups, with no specific phenotype distribution found.
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