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A clinical study using non-vital maxillary central incisors exhibiting acute apical periodontitis was carried out to evaluate the incidence of post-operative pain after biomechanical preparation and dressing with a calcium-hydroxide paste or a corticosteroid-antibiotic solution. Sixty teeth from 48 patients were prepared and dressed on the first visit and re-evaluated clinically 7 days later. No difference was observed in the incidence of post-operative pain between the two groups.
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Fava (1998) studied this question.
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