Key result
Recruitment at low versus high recruitment centers was associated with a similar rate of death, MI, or stroke (7.3% vs 8.4%; HR 0.86; P=0.27) but significantly lower all-cause mortality.
Why the study?
Does recruitment at low versus high recruitment centers affect clinical outcomes and observed treatment effects in patients with acute coronary syndrome?
Population
4018 patients with acute coronary syndrome from the ISAR-REACT 5 trial
Comparison
Recruitment at low recruitment centers (LRCs) vs Recruitment at high recruitment centers (HRCs)
Design
Editorial
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Recruitment practices and center volume in multicenter trials can introduce bias, as patients recruited at low recruitment centers may have lower baseline risk profiles, potentially modifying observed treatment effects.
Does recruitment at low versus high recruitment centers affect clinical outcomes and observed treatment effects in patients with acute coronary syndrome?
Hazard Ratio: 0.86
Absolute Event Rate: 7.3% vs 8.4%
p-value: p=0.27
Recruitment practices and center volume in multicenter trials can introduce bias, as patients recruited at low recruitment centers may have lower baseline risk profiles, potentially modifying observed treatment effects.
A 2021 study conducted an editorial in Acute coronary syndrome (n=4,018). Recruitment at low recruitment centers (LRCs) vs. Recruitment at high recruitment centers (HRCs) was evaluated on Death, myocardial infarction, or stroke (HR 0.86, p=0.27). Recruitment at low versus high recruitment centers was associated with a similar rate of death, MI, or stroke (7.3% vs 8.4%; HR 0.86; P=0.27) but significantly lower all-cause mortality.
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