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January 1, 2008Cellular Physiology and Biochemistry

The Protective Effect of Egr-1 Antisense Oligodeoxyribonucleotide on Myocardial Injury Induced by Ischemia-reperfusion and Hypoxia-reoxygenation

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Key result

Egr-1 AS-ODN attenuates myocardial injury and inflammation from ischemia-reperfusion in preclinical models.

Why the study?

Does Egr-1 AS-ODN reduce myocardial injury and inflammation in rat models of ischemia-reperfusion and hypoxia-reoxygenation?

Population

Sprague-Dawley rat myocardial ischemia-reperfusion model and cultured cardiomyocyte hypoxia-reoxygenation…

Design

Preclinical

Authors

YZYanmei ZhangChinese Academy of Tropical Agricultural SciencesGSGanggang ShiSecond Hospital of Tianjin Medical UniversityJZJinhong ZhengShantou University

Discussion

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Implication

Hypothesis-generating for Egr-1 targeting in myocardial ischemia-reperfusion; clinical translation untested and should not yet change practice.

Structured PICO

Does Egr-1 AS-ODN reduce myocardial injury and inflammation in rat models of ischemia-reperfusion and hypoxia-reoxygenation?

P
Population
Sprague-Dawley rat myocardial ischemia-reperfusion model and cultured cardiomyocyte hypoxia-reoxygenation model.
I
Intervention
Egr-1 antisense oligodeoxyribonucleotide (AS-ODN) transfected into myocardial tissues and cells
O
Outcome
Degree of injury and inflammation of myocardial tissues and cells (measured by hemodynamic parameters, myeloperoxidase, cardiac troponin I, tumor necrosis factor-alpha, morphology, spontaneous beat, and cell viability)surrogate

Egr-1 AS-ODN protects against myocardial ischemia-reperfusion injury in preclinical models, suggesting Egr-1 as a potential therapeutic target.

Cite This Study

Zhang et al. (2008) studied Myocardial ischemia-reperfusion injury. Egr-1 antisense oligodeoxyribonucleotide (AS-ODN) was evaluated on Hemodynamic parameters, myeloperoxidase, cardiac troponin I, tumor necrosis factor-alpha, morphology, spontaneous beat and cell viability. Egr-1 antisense oligodeoxyribonucleotide significantly attenuated injury and inflammation of myocardial tissues caused by ischemia-reperfusion in vivo and hypoxia-reoxygenation in vitro.

synapsesocial.com/papers/6aa7c7db0b3c98ee51310b4ehttps://doi.org/10.1159/000185548
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Also Consider

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  5. 5Egr-1: is it always immediate and early?2000 · 51 citations