Idiopathic extensive acanthosis nigricans with a variant of the epidermal growth factor receptor

Acanthosis nigricans (AN) is a common condition seen in individuals as a consequence of insulin resistance states, other metabolic disorders, malignancy, genetic syndromes, and drugs. This article presents a severe, childhood-onset case of AN that was of unclear etiology. Whole-genome sequencing identified a variant of epidermal growth factor receptor (EGFR), a receptor involved in keratinocyte proliferation and fibroblast migration.1