Why the study?
The study aimed to analyze helical computer-assisted tomography findings in patients with pulmonary hypertension associated with left-to-right shunts to estimate pulmonary vascular resistance.
Do helical computer-assisted tomography (CAT) derived lung volume ratios correlate with invasive hemodynamic parameters in pediatric patients with pulmonary hypertension complicating left-to-right shunts?
Cross-Sectional (n=30)
No
Do helical computer-assisted tomography (CAT) derived lung volume ratios correlate with invasive hemodynamic parameters in pediatric patients with pulmonary hypertension complicating left-to-right shunts?
Helical CAT-derived lung volume ratios (Lo, Ate, Lo&Ate) correlate significantly with invasive hemodynamic parameters and can reliably estimate pulmonary vascular resistance in pediatric patients with pulmonary hypertension associated with left-to-right shunts.
Answers are grounded in this paper and cite their sources.
May support noninvasive PVR estimation in shunt-related infant PH; leaves open prospective validation before practice change.
The present study analyzed the helical computer-assisted tomography (CAT) findings in 30 patients with pulmonary hypertension (PH) associated with left-to-right shunts; specifically, ventricular septal defect, 23; atrioventricular septal defect, 6; patent ductus arteriosus, 1. Eight patients had 21 trisomy. Age ranged from 1 to 18 (mean, 4.1) months, and body weight ranged from 2.6 to 10.7 (mean, 4.9) kg. In all patients, the chest CAT revealed patchy areas of high and low attenuation (mosaic pattern) and regional atelectasis in the lung fields. The volume of low attenuated lesions and of atelectasis, and the total lung volume were derived from integration of areas measured on the CAT image. The ratios of low attenuated lesion/total lung volume (Lo), volume of atelectasis/ total lung volume (Ate) and low attenuated lesion and volume of atelectasis/total lung volume (Lo&Ate) were compared with hemodynamic parameters measured at cardiac catheterization. The pulmonary to systemic resistance ratio correlated with Lo (r=0.61, p<0.01) and Lo&Ate (r=0.69, p<0.01), whereas the pulmonary vascular resistance correlated with Ate (r=0.53, p<0.01). Lo, Ate and Lo&Ate in the chest CAT are reliable parameters that can be used to estimate pulmonary vascular resistance in patients with PH associated with left-to-right shunts.
No takes yet. Share an insight, caveat, or question.
Kubo et al. (2001) conducted a cross-sectional in Pulmonary hypertension associated with left-to-right shunts (n=30). Chest CAT parameters (Lo, Ate, Lo&Ate) was evaluated on Correlation between pulmonary to systemic resistance ratio (Rp/Rs) and the volume of low attenuated lesion and atelectasis/total lung volume ratio (Lo&Ate) (r=0.69, p=<0.01).
Synapse has enriched 10 related papers. Consider them for comparative context: