Key result
Chronic anoxia at 5°C cuts cardiac power ~330-fold vs normoxia, driven by decreased cardiac output.
Population
Red-eared sliders (Trachemys scripta)
Comparison
Cold acclimation and anoxic exposure vs Normoxia at 22 °C
Design
Preclinical
Authors
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Highlights extreme anoxia tolerance via cardiac suppression in turtles; leaves open translation to mammalian cardioprotection.
Effect estimate: 330-fold reduction
The remarkable cardiovascular down-regulation and suppression of the Pasteur effect during cold anoxia enable red-eared sliders to withstand prolonged anoxia.
Hicks et al. (2000) studied this question. Anoxic exposure and cold acclimation (5 °C) vs. Normoxia at 22 °C was evaluated on Systemic cardiac power output (PO(sys)) (330-fold reduction). Chronic anoxia at 5 °C reduced systemic cardiac power output 330-fold compared to normoxia at 22 °C, driven by massive decreases in cardiac output and heart rate.
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