Key result
Chronic heart failure is linked to CD4+ T cell dysfunction shifting toward Th1 and Th17.
Why the study?
The role and mechanism of CD4+ T cell dysfunction in the disease process of chronic cardiac failure were not fully understood.
Population
100 CHF patients and 50 healthy volunteers
Comparison
Ischemia vs non-ischemia, heart function III-IV vs I-II, event vs non-event, and healthy controls
Design
Observational study with subgroup comparisons
Authors
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CD4+ imbalance associated with heart failure severity; leaves open whether Th1/Th17 modulation alters progression.
Observational (n=150)
p-value: p=< 0.05
Chronic heart failure is associated with CD4+ T cell dysfunction, characterized by immune activation and shifts towards Th1 and Th17 phenotypes that correlate with disease severity.
Cai et al. (2016) conducted an observational in Chronic cardiac failure (CHF) (n=150). Chronic cardiac failure vs. Healthy volunteers was evaluated on CD4+ T cell dysfunction markers (Th1/Th2 and Th17/Treg balances) (p=< 0.05). Chronic cardiac failure was associated with CD4+ T cell dysfunction, showing deviations from the Th1/Th2 balance towards Th1 and from the Th17/Treg balance towards Th17 (P < 0.05).
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