Answers are grounded in this paper and cite their sources.
Synthetic study demonstrates asymmetric synthesis of caged pentacycloundecane compounds using coupled enzymatic resolution and hydride transfer, indicating a viable route to chiral scaffolds.
Caged molecules featuring the pentacycloundecane framework and related substructures represent an exciting class with numerous potential applications, yet reports of their asymmetric syntheses are scarce. In this work, we report a method for the asymmetric synthesis of these compounds, featuring the combined effect of a lipase-catalyzed kinetic resolution and the unique ability of the hydroxyketone starting materials to racemize via an intramolecular hydride transfer. This particular racemization, although previously reported, had, until this study, not been utilized in a synthetic context.
No takes yet. Share an insight, caveat, or question.
Cooper et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: