Key result
Carotid bodies ≥2.5 mm linked to increased left atrial diameter and vascular resistance in hypertension.
Why the study?
This study aimed to investigate the effect of carotid body size on target organ damage and its potential association with relevant parameters in patients with hypertension.
Is larger carotid body size associated with indicators of target organ damage in patients with hypertension?
Cohort (n=49)
No
Is larger carotid body size associated with indicators of target organ damage in patients with hypertension?
Effect estimate: AUC 0.794 (95% CI 0.667-0.920)
p-value: p=<0.001
Carotid body enlargement in hypertensive patients is associated with increased left atrial diameter and total vascular resistance, suggesting a link to target organ damage.
Larger carotid body size was associated with left atrial enlargement in hypertension; leaves open whether measurement aids risk stratification or warrants prospective validation.
Aim This study aimed to investigate the effect of carotid body size on target organ damage in patients with hypertension and its potential association with relevant parameters. Method A total of 49 participants diagnosed with hypertension or newly diagnosed hypertension, who were admitted to the outpatient clinic between January 2023 and April 2024, were included in the study. The size of the carotid body was measured using computed tomography. The study population was categorized into two groups based on a carotid body size threshold of 2.5 mm. Transthoracic echocardiography was performed, and blood pressure measurements and pulse wave analyses were examined non-invasively. Results The mean age of the participants was 54.93 ± 10.85 years, and 36.7% (n=18) were male. In the group with a larger carotid body size, the left atrial diameter, total vascular resistance, and pulse-adjusted augmentation index (AIx@75) were higher, while the left atrial strain values and cardiac index were lower compared to those in the group with a smaller carotid body size (p <0.05). Multivariate linear regression analysis and ROC analysis were performed to determine the parameters that were significantly associated with carotid body size, and it was revealed that left atrial diameter (AUC: 0.794 (0.667-0.920), p<0.001) and total vascular resistance (AUC: 0.819 (0.700-0.938), p<0.001) were independently associated with carotid body size. Conclusion This study suggests that processes leading to carotid body enlargement or those caused by this enlargement in patients diagnosed with hypertension, may affect parameters such as left atrial diameter, left atrial strain, AIx, and total vascular resistance, which could serve as indicators of target organ damage.
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Eşki et al. (2025) conducted a cohort in Hypertension (n=49). Carotid body size ≥ 2.5 mm vs. Carotid body size < 2.5 mm was evaluated on Left atrial diameter predicting carotid body size ≥ 2.5 mm (AUC 0.794, 95% CI 0.667-0.920, p=<0.001). In patients with hypertension, a carotid body size of ≥ 2.5 mm was independently associated with increased left atrial diameter (AUC 0.794) and total vascular resistance.
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