Key result
Adult growth hormone deficiency is linked to NAFLD development via altered hepatic metabolism.
Why the study?
The precise mechanisms by which growth hormone and insulin-like growth factor-I exert their effects in the liver require clarification in the context of emerging nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in adult growth hormone deficiency.
Answers are grounded in this paper and cite their sources.
NAFLD and NASH have emerged as important comorbidities in adult growth hormone deficiency, highlighting the essential metabolic roles of GH and IGF-I in the liver.
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) play essential roles in growth in childhood, and continue to have important metabolic actions in adults. Adult growth hormone deficiency (AGHD) is characterized by increased visceral adiposity, abnormal lipid profiles, premature atherosclerosis, decreased quality of life, and increased mortality. Recently, case reports and several clinical studies suggest that GHD state in adults is associated with an increased prevalence of nonalcoholic fatty liver disease (NAFLD) and progression to nonalcoholic steatohepatitis (NASH) or liver cirrhosis. As a mechanistic insight, growing evidence has revealed that GH as well as IGF-I play essential roles in the liver. Further investigation is necessary to clarify the precise mechanisms by which GH and IGF-I exert their effects in the liver; however, it should be noted that NAFLD/NASH has emerged as an important comorbidity in AGHD.
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Yutaka Takahashi (2012) conducted a review in Adult growth hormone deficiency (AGHD) and Nonalcoholic fatty liver disease (NAFLD). Growth hormone (GH) and insulin-like growth factor-I (IGF-I) was evaluated. Growth hormone and insulin-like growth factor-I play essential roles in hepatic metabolism, and adult growth hormone deficiency is closely associated with the development of nonalcoholic fatty liver disease.
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