Key result
Carotid plaque hemorrhage on MRI linked to ~6-fold greater risk of ipsilateral DWI abnormalities.
Why the study?
Does the presence of carotid plaque hemorrhage on MR imaging associate with increased thromboembolic activity in patients with symptomatic carotid disease?
Population
51 patients (23 women, 28 men; mean age 72 ± 11 years) with high-grade symptomatic carotid stenosis.
Comparison
Presence of carotid plaque hemorrhage depicted… vs Absence of carotid plaque hemorrhage
Design
Cohort
Authors
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Supports MRI plaque hemorrhage assessment for risk stratification in symptomatic carotid stenosis; hypothesis-generating for intervention trials.
Observational (n=51)
Does the presence of carotid plaque hemorrhage on MR imaging associate with increased thromboembolic activity in patients with symptomatic carotid disease?
Odds Ratio: 6.2 (95% CI 1.7–21.8)
p-value: p=<.05
Carotid plaque hemorrhage detected by MRI is a strong marker of active thromboembolic activity in patients with symptomatic carotid stenosis.
Altaf et al. (2010) conducted an observational in High-grade symptomatic carotid stenosis (n=51). Carotid plaque hemorrhage vs. Absence of carotid plaque hemorrhage was evaluated on Ipsilateral abnormalities at diffusion-weighted imaging (OR 6.2, 95% CI 1.7-21.8, p=<.05). Carotid plaque hemorrhage on MR imaging significantly increased the risk for ipsilateral abnormalities on diffusion-weighted imaging (OR 6.2; 95% CI 1.7-21.8; P<0.05).
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