Analysis for oestradiol bis-tert-butyldimethylsilyl ether by gas chromatography/mass spectrometry (GC/MS) with selected reaction monitoring ([M]+.----[M-C4H9]+) using a tandem double-focusing/quadrupole instrument gave a detection limit below 10 pg. During analyses of a plasma extract, the selectivity of detection was superior to conventional selected ion monitoring. A parent ion resolution of 5000 was used to eliminate detection of all components but the chosen analyte.
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Gaskell et al. (1985) studied this question.
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