Key result
Intracranial aneurysms linked to higher ascending aorta augmentation index and carotid asymmetry versus healthy controls.
Why the study?
Differences in peripheral and central arterial blood pressure profiles in patients with intracranial aneurysms compared with age-matched controls were not well characterized.
Are there differences in peripheral and central arterial blood pressure profiles (augmentation index) in patients with intracranial aneurysms compared with age-matched controls?
Case-Control (n=346)
Are there differences in peripheral and central arterial blood pressure profiles (augmentation index) in patients with intracranial aneurysms compared with age-matched controls?
Absolute Event Rate: 29.8% vs 25.6%
Patients with intracranial aneurysms exhibit significant differences in arterial augmentation index, suggesting a role for hemodynamic stress factors in aneurysm formation.
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Higher augmentation index was associated with intracranial aneurysms; hypothesis-generating for hemodynamic factors and requires prospective validation before clinical consideration.
Turner et al. (2001) conducted a case-control in Intracranial aneurysms (n=346). Intracranial aneurysms vs. Age-matched healthy controls was evaluated on Ascending aorta augmentation index (AI). Patients with intracranial aneurysms had a higher ascending aorta augmentation index (29.8% vs 25.6%) and significant asymmetry in carotid artery AI (p=0.002) compared with healthy controls.
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