The joint action of constituents in a mixture poses statistical questions of experimental design. These are discussed with particular reference to similar action and independent action. Designs previously put forward are compared by regarding these types of joint action as special cases of general models including additional parameters, and then arranging that these parameters are estimated as efficiently as possible. This procedure enables recommendations to be made for the types of action considered, and the proposals are found to difTer from those put forward earlier.
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Abdelbasit et al. (1982) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: