Key result
Therapeutic risperidone linked to pediatric syncope driven by sinus arrest with prolonged pauses.
Why the study?
Although risperidone is known to affect the cardiac conduction system, symptomatic bradycardia had not been reported previously in children.
Case Report (n=1)
Risperidone at therapeutic doses can cause symptomatic bradycardia and sinus arrest in children, necessitating close monitoring.
May warrant ECG monitoring with risperidone in children; Level 5 evidence leaves risk magnitude and generalizability open.
Risperidone has been reported as a well-tolerated antipsychotic in children. The most common side effects of risperidone are anxiety, headaches, insomnia, and agitation, which frequently appear with high doses. Although it is known that risperidone affects the cardiac conduction system, symptomatic bradycardia has not been reported previously in children. We report a child who developed syncope because of sinus arrest with long pauses (>3 seconds) with therapeutic doses of risperidone. This case suggests that close monitoring is mandatory even during therapeutic treatment with risperidone.
No takes yet. Share an insight, caveat, or question.
Olgun et al. (2009) conducted a case report in Syncope due to sinus arrest (n=1). Risperidone was evaluated on Syncope because of sinus arrest with long pauses (>3 seconds). Therapeutic doses of risperidone caused syncope due to sinus arrest with long pauses (>3 seconds) in a child, highlighting the need for close monitoring.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: