Key result
Adipose tissue inflammation linked to obesity complications including insulin resistance and T2D.
Why the study?
Chronic low-grade adipose tissue inflammation impairs insulin signaling and increases the risk of insulin resistance and type 2 diabetes, warranting an updated clinical perspective on obesity-associated complications in humans.
Design
Review
Authors
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Adipose inflammation links obesity to metabolic risk; leaves open whether targeting it improves clinical outcomes.
This review highlights the systemic nature of adipose tissue inflammation in obesity and its role in impairing insulin signaling and increasing the risk of type 2 diabetes.
Tam et al. (2013) conducted a review in Obesity and metabolic dysfunction. Adipose tissue inflammation was evaluated. This review discusses the role of adipose tissue inflammation in the development of obesity-associated complications, including insulin resistance and type 2 diabetes, across various clinical scenarios.
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