Key result
Cardiac ion channel variants are linked to ~20% of Sudden Infant Death Syndrome cases.
Population
Infants with Sudden Infant Death Syndrome (SIDS)
Design
Review
Authors
Loading...
Supports targeted genetic evaluation in SIDS; leaves open whether routine postmortem testing and family screening improve outcomes.
Cardiac channelopathies, including long QT, short QT, Brugada syndrome, and CPVT, may account for 10-20% of SIDS cases, highlighting the importance of postmortem genetic testing and family screening.
Tfelt‐Hansen et al. (2011) conducted a review in Sudden infant death syndrome (SIDS). Genetic variants in cardiac channelopathy susceptibility genes was evaluated. Genetic variants in cardiac ion channel or associated proteins are proposed to cause 10-20% of Sudden Infant Death Syndrome cases, with 10 susceptibility genes implicated to date.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: