Key result
Lower body negative pressure shifts the respiratory chemoreflex operating point leftwards without altering sensitivity.
Why the study?
Does cerebral hypoperfusion modify the respiratory chemoreflex during orthostatic stress?
Population
Subjects undergoing orthostatic stress testing (demographics and sample size not stated in abstract)
Comparison
Lower body negative pressure at different CO2… vs Supine control
Design
Other
Authors
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Orthostatic cerebral hypoperfusion may shift chemoreflex operating point; hypothesis-generating for its role in clinical orthostatic intolerance or HF.
Does cerebral hypoperfusion modify the respiratory chemoreflex during orthostatic stress?
Absolute Event Rate: 1.06% vs 1.36%
p-value: p=0.087
Postural reductions in cerebral blood flow modify the central respiratory chemoreflex by moving its operating point, likely due to attenuated CO2 washout from the brain.
Ogoh et al. (2013) studied this question. Lower body negative pressure (LBNP) at different CO2 levels vs. Supine control was evaluated on Sensitivity of the linear relationship between pulmonary minute ventilation and end-tidal CO2 (p=0.087). Orthostatic stress induced by lower body negative pressure shifted the respiratory chemoreflex operating point leftwards without significantly changing sensitivity (1.36 to 1.06 l/min/mmHg; P=0.087).
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