Answers are grounded in this paper and cite their sources.
An efficient and highly stereoselective one-pot, four-component synthesis of functionalized tricyclic chromanes has been achieved through an organocatalyzed quadruple domino reaction. The reaction sequence involves an oxa-Michael/Michael/Michael/aldol condensation between alcohols, 2 equiv of acrolein, and nitrochromenes to generate the pharmaceutically important tricyclic chromanes bearing three contiguous stereogenic centers including a chiral tetrasubstituted carbon center in good domino yields (30-70%) and excellent diastereo- and enantioselectivities (>20:1 dr and >99% ee).
No takes yet. Share an insight, caveat, or question.
Kumar et al. (2018) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: