Key result
Women with +APOE4 and Alzheimer's family history exhibit more advanced brain aging than male counterparts.
Why the study?
Determining the differential effect of Alzheimer's disease risk factors on brain aging in women versus men is critical to understanding sex differences in pathways toward the disease in cognitively intact adults.
Population
1067 cognitively normal adults across four neuroimaging datasets
Comparison
Sex differences across AD risk factors (family history of AD, +APOE4) and modifiable factors
Design
Cross-sectional study
Authors
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Supports sex-specific preclinical Alzheimer's brain aging patterns; hypothesis-generating and requires longitudinal studies before informing risk stratification.
Cross-Sectional (n=1,067)
Yes
Women with a family history of Alzheimer's disease and APOE4 genetic risk exhibit more advanced brain aging than men, highlighting sex-specific trajectories in preclinical disease.
Subramaniapillai et al. (2021) conducted a cross-sectional in Cognitively normal adults at risk for Alzheimer's Disease (n=1,067). Female sex combined with family history of AD and +APOE4 genotype vs. Male sex with the same risk factors was evaluated on Brain Age Gap (BAG). Women with a family history of Alzheimer's disease and the +APOE4 genotype exhibited more advanced brain aging compared to their male counterparts.
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