Key result
Borna disease virus infection is linked to negative syndromes in schizophrenic patients.
Why the study?
The relationship between Borna disease virus infection and positive and negative syndromes in schizophrenia was unclear.
Is Borna disease virus (BDV) infection associated with positive and negative syndromes in schizophrenic patients?
Cross-Sectional (n=67)
Is Borna disease virus (BDV) infection associated with positive and negative syndromes in schizophrenic patients?
p-value: p=< 0.05
Borna disease virus infection with induction of BDV p24 antibodies may be associated with negative syndromes in schizophrenic patients.
BDV p24 antibodies may link to negative syndromes in schizophrenia; leaves open causality and requires prospective studies before any clinical consideration.
The relationship between Borna disease virus (BDV) infection and positive and negative syndromes in schizophrenia was investigated. By nested RT-PCR and Western blotting, BDV-specific RNA and anti-BDV antibodies were examined in blood from 67 schizophrenic patients (DSM-III-R) in Japan, and the psychometric properties of the Positive and Negative Syndrome Scale (PANSS) were analyzed. There were significant (p < 0.05) differences in the composite index denoting the positive minus negative difference indicating a dominant contribution by negative items, and the proportion of negative type (positive minus negative value below zero) patients, between patients positive and negative for anti-BDV p24 antibodies. It is possible that BDV infection with induction of BDV p24 antibodies may be associated with negative syndromes in schizophrenic patients.
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Iwahashi et al. (1998) conducted a cross-sectional in Schizophrenia (n=67). Borna disease virus (BDV) infection vs. Patients negative for anti-BDV p24 antibodies was evaluated on Composite index denoting the positive minus negative difference on the PANSS and proportion of negative type patients (p=< 0.05). Borna disease virus infection, indicated by anti-BDV p24 antibodies, was significantly associated with negative syndromes in schizophrenic patients (p < 0.05).
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