What does this research mean for the field?

Adult men with a secundum atrial septal defect have reduced long-term survival compared to the general population and a higher risk of morbidity including heart failure and dysrhythmias, whereas women do not experience excess mortality. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 16, 2015European Heart JournalOpen Access

Secundum atrial septal defect is associated with reduced survival in adult men

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Secundum atrial septal defect (ASD2) (n=2207). Intervention: Male sex vs. Age- and sex-matched general population. Primary outcome: Survival compared with age- and sex-matched general population (p=0.015).

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Key result

Secundum ASD in adult men is linked to worse survival and ~91% higher HF risk.

P=0.015
n=2,207

Authors

JKJoey M. KuijpersAmsterdam Neuroscience TBTeun van der BomUniversity Medical Center ARAnnelieke C.M.J. van RielBoston Children's Hospital

Discussion

Member takes

Implication

Men with ASD2 have excess mortality and morbidity versus peers; observational data leave open whether sex-specific surveillance improves outcomes.

Study Design

Type

Cohort (n=2,207)

Multicenter

Yes

PICO

Population

2,207 adult patients with secundum atrial septal defect from a Dutch national registry, followed for a cumulative 13,584 patient-years.

Exposure / Comparator

Male sex vs Age- and sex-matched general population

Primary Outcome

Survival compared with age- and sex-matched general population, p=0.015

Main Result

p-value: p=0.015

Cite This Study

Kuijpers et al. (2015) conducted a cohort in Secundum atrial septal defect (ASD2) (n=2,207). Male sex vs. Age- and sex-matched general population was evaluated on Survival compared with age- and sex-matched general population (p=0.015). Adult men with a secundum atrial septal defect have worse survival than a sex-matched general population (P=0.015) and a higher risk of morbidities including heart failure (OR 1.91; 95% CI 1.06-3.43).

synapsesocial.com/papers/6aa80521edd3d119df57452c https://doi.org/10.1093/eurheartj/ehv097

Topics

Heart failure HFrEF treatment

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Implication

Men with ASD2 have excess mortality and morbidity versus peers; observational data leave open whether sex-specific surveillance improves outcomes.

Secundum atrial septal defect is associated with reduced survival in adult men

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

Topics

Secundum atrial septal defect is associated with reduced survival in adult men

Discussion

Member takes

Implication

Study Design

PICO

Main Result

Cite This Study

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