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The oxygen dissociation curve of whole blood containing Hb Malmö (β 97 (FG 4) Histidine → Glutamine), an abnormal Hb associated with familial erythrocytosis, was determined. It was found to be hyperbolic with a reduced Hill's n value of 1.5 indicating decreased haem‐haem interaction. The curve was shifted to the left with a P50 value of only 13 mm Hg (37.0° C, pH 7.40). Whole blood studies suggest that Hb Malmö exhibits a Bohr effect.
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Stig Berglund (1972) studied this question.
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