Key result
Oral polio vaccine linked to acute disseminated encephalomyelitis in a 27-year-old woman.
Case Report (n=1)
This case report highlights a rare occurrence of acute disseminated encephalomyelitis following administration of the oral polio vaccine.
Possible ADEM link to oral polio vaccine; leaves open causality and should not alter vaccination practice.
A 27-year-old woman presented with acute paresis after taking an oral polio vaccine (OPV). Deep tendon reflexes were preserved, needle electromyography showed no neurogenic changes, and there were no lesions on spine magnetic resonance imaging (MRI), suggesting that motor neurons of the spinal cord were not affected. Brain MRI showed abnormal lesions in the tegmentum of the upper pons, left cerebral peduncles, truncus of the corpus callosum, and right parietal lobe. Cerebrospinal fluid revealed mild pleocytosis. The most probable diagnosis was acute disseminated encephalomyelitis associated with OPV.
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Shibazaki et al. (2006) conducted a case report in Acute Disseminated Encephalomyelitis (n=1). Oral polio vaccine (OPV) was evaluated on Clinical symptoms and MRI findings. A 27-year-old woman developed acute disseminated encephalomyelitis, presenting with acute paresis and brain MRI abnormalities, after receiving the oral polio vaccine.
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