Key result
Complete resection cuts intracardiac leiomyomatosis recurrence ~89% vs incomplete resection.
Why the study?
Intracardiac leiomyomatosis incomplete resection and recurrence carry high morbidity and mortality, but whether estrogen deprivation therapies benefit patients with primary unresectable disease remains unclear.
Does estrogen deprivation therapy reduce recurrence and improve resection rates in premenopausal women with primary unresectable intracardiac leiomyomatosis?
Population
114 patients with intracardiac leiomyomatosis from 70 papers
Comparison
Estrogen deprivation therapy vs ovarian preservation or no estrogen deprivation
Design
Systematic review and meta-analysis
Authors
Loading...
May support complete resection plus estrogen deprivation to lower recurrence in premenopausal intracardiac leiomyomatosis; extends sparse data on multimodal therapy for this rare disease.
Systematic Review (n=114)
Does estrogen deprivation therapy reduce recurrence and improve resection rates in premenopausal women with primary unresectable intracardiac leiomyomatosis?
Absolute Event Rate: 4.29% vs 37.84%
p-value: p=<0.0001
Estrogen deprivation therapies, including BSO-based surgery and GnRHa, may decrease tumor burden and reduce recurrence rates in premenopausal women with intracardiac leiomyomatosis.
Liang et al. (2021) conducted a systematic review in Primary unresectable intracardiac leiomyomatosis (ICLM) (n=114). Complete surgical resection vs. Incomplete surgical resection was evaluated on Recurrence or regrowth of residual tumor (p=<0.0001). In premenopausal women with intracardiac leiomyomatosis, complete resection significantly reduced the recurrence rate compared to incomplete resection (4.29% vs 37.84%), while estrogen deprivation therapy further minimized progression risk.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: