Key result
Human insulin is not associated with more frequent monthly hypoglycemia compared to animal insulin.
Why the study?
Does human insulin increase the frequency of hypoglycaemia or reduce awareness of hypoglycaemia compared to animal insulin in Type 1 diabetic patients?
Population
628 Type 1 diabetic patients, mean age 28 years, duration of diabetes 19 years, participating in the…
Comparison
Human insulin vs Animal insulin (beef or pork)
Design
Cross-sectional
Authors
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No increased hypoglycaemia frequency with human versus animal insulin; leaves open causality, awareness effects, and need for prospective trials.
Cross-Sectional (n=628)
Does human insulin increase the frequency of hypoglycaemia or reduce awareness of hypoglycaemia compared to animal insulin in Type 1 diabetic patients?
Absolute Event Rate: 66% vs 55%
p-value: p=0.06
Human insulin use does not substantially increase the frequency of hypoglycaemia or reduce awareness compared to animal insulin in Type 1 diabetic patients.
Orchard et al. (1991) conducted a cross-sectional in Type 1 diabetes (n=628). Human insulin vs. Animal insulin was evaluated on Hypoglycaemic reactions at least monthly in the last year (p=0.06). Human insulin use was not associated with a significantly higher frequency of at least monthly hypoglycaemic reactions compared to animal insulin (66% vs 55%; p=0.06).
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