What question did this study set out to answer?

To evaluate the real-world efficacy, safety, and impact on concomitant antiseizure medications of cenobamate in adult patients with drug-resistant epilepsy.

May 2, 2025SeizureOpen Access

Efficacy and safety of Cenobamate: a multicenter, retrospective evaluation of real-world clinical practice

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Authors

MBMagdalena BosakJagiellonian University HPHanna PodrazaUniversity of Szczecin DWDorota Włoch-KopećJagiellonian University

Discussion

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Implication

Retrospective multicenter study demonstrates significant seizure reduction in adults with drug-resistant epilepsy, indicating Cenobamate's potential to simplify polytherapy regimens.

Key Points

To evaluate the real-world efficacy, safety, and impact on concomitant antiseizure medications of cenobamate in adult patients with drug-resistant epilepsy.
Conducted a retrospective, multicenter review across 19 centers in Poland analyzing medical records of adult patients with drug-resistant epilepsy.
Included N=475 patients (median age 37 years) treated with cenobamate (median maximal daily dose 250 mg) for at least six months.
Evaluated the primary endpoint of ≥50% reduction in seizure frequency alongside adverse events and changes in concomitant antiseizure medications.
Treatment resulted in a ≥50% reduction in seizure frequency in 61.9% of patients, with 16.5% achieving complete seizure freedom during the final three months of observation.
Concomitant antiseizure medication burden decreased, with 69.7% of patients reducing or discontinuing other antiseizure drugs.
Adverse events occurred in 48.8% of patients (most commonly somnolence and dizziness), leading to treatment discontinuation in 12.0%, with no cases of severe dermatological reactions.

Cite This Study

Bosak et al. (2025) studied this question.

synapsesocial.com/papers/6aa808d595a386ecd3876aa8 https://doi.org/10.1016/j.seizure.2025.05.002

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Implication

Retrospective multicenter study demonstrates significant seizure reduction in adults with drug-resistant epilepsy, indicating Cenobamate's potential to simplify polytherapy regimens.

Efficacy and safety of Cenobamate: a multicenter, retrospective evaluation of real-world clinical practice

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy and safety of Cenobamate: a multicenter, retrospective evaluation of real-world clinical practice

Discussion

Member takes

Implication

Key Points

Cite This Study

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