Key result
Perfusion imaging refines patient selection for thrombolysis and endovascular thrombectomy in acute ischemic stroke.
Why the study?
Intravenous tissue plasminogen activator has limitations including narrow therapeutic window, contraindications, and low efficacy in large vessel occlusion, prompting updates in treatment strategies.
This review highlights updates in thrombolytic and catheter-based treatments for acute ischemic stroke, including patient selection in extended time windows using perfusion imaging.
Acute ischemic stroke is the leading cause of disability and among the leading causes of mortality worldwide. Intravenous tissue plasminogen activator has been a cornerstone for treatment of acute ischemic stroke for more than 20 years; however, its use is limited due to a narrow therapeutic window, several contraindications, and low efficacy to recanalize the artery in large vessel occlusion. Recently, the addition of endovascular mechanical thrombectomy of large artery occlusion has revolutionized the stroke treatment for most disabling strokes. The paper reviews updates to the thrombolytic treatment as well as catheter-based treatment, and results from recent trials in the selection of patients in an extended time window using perfusion imaging.
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Patel et al. (2020) conducted a review in Acute ischemic stroke. Thrombolytic and catheter-based treatments was evaluated. This review summarizes updates to thrombolytic and catheter-based treatments for acute ischemic stroke, including recent trials on patient selection using perfusion imaging.
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