Key result
Non-human primate models advance enteric viral infection research and improve translatability to human gastrointestinal diseases.
Non-human primates provide a highly translatable pre-clinical model for studying enteric viral infections and gastrointestinal autoimmune disorders.
NHP models merit consideration for enteric virus studies; extends preclinical literature but leaves translation to human therapies open.
There is an important role non-human primates (NHP) play in biomedical research. Phylogenetic proximity of any of the NHP species to Homo sapiens assures that much better translatability of research outcomes from model studies involving human diseases can be achieved than from those generated with other pre-clinical systems. Our group and others used during past two decades NHPs in research directed towards viral and autoimmune disorders of the gastrointestinal tract. This review summarizes progress made in the area of enteric viral infections including its applicability to human disease.
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Karol Sestak (2018) conducted a review in Enteric viral infections. Non-human primate models was evaluated. Non-human primate models have been utilized over the past two decades to advance research on enteric viral infections and improve translatability to human gastrointestinal diseases.
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