Key result
Higher total and abdominal fat linked to ~465% greater NAFLD risk.
Why the study?
This study aimed to investigate the relationship between body composition and fatty liver disease and determine cut-off points for predicting NAFLD.
Is body composition associated with the risk of non-alcoholic fatty liver disease?
Cross-Sectional (n=2,160)
No
Is body composition associated with the risk of non-alcoholic fatty liver disease?
Odds Ratio: 5.646 (95% CI 4.535–7.029)
p-value: p=<0.001
Total and abdominal fat percentages measured by DEXA are strong predictors of NAFLD, providing specific risk cut-offs for men and women.
May aid NAFLD risk stratification via DXA; leaves open prospective validation of cut-offs before clinical adoption.
Non-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver. This cross-sectional study aimed to investigate the relationship between body composition and fatty liver and determine of cut-off point for predicting NAFLD. Samples were selected from the nutrition clinic from 2016 to 2017 in Tehran, Iran. The liver steatosis was calculated using the CAP score through the FiroScan™ and body composition was measured using the dual-energy X-ray absorptiometry scan method. A total of 2160 patients participated in this study, 745 (34.5%) subjects had NAFLD. We found that fat-free tissue was inversely and fat tissue was directly correlated with the risk of NAFLD in almost all factors and the risk of developing NAFLD increases if the total fat exceeds 32.23% and 26.73% in women and men and abdominal fat exceeds 21.42% and 13.76% in women and men, respectively. Finally, we realized that the total fat percent had the highest AUC (0.932 for men and 0.917 for women) to predict the risk of NAFLD. Overall, the likelihood of NAFLD development rose significantly with increasing the amount of total fat and abdominal fat from the cut-off point level.
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Ariya et al. (2021) conducted a cross-sectional in Non-alcoholic fatty liver disease (NAFLD) (n=2,160). Total and abdominal body fat vs. Lower body fat was evaluated on Presence of non-alcoholic fatty liver disease (NAFLD) associated with abdominal fat mass (OR 5.646, 95% CI 4.535-7.029, p=<0.001). Higher total and abdominal fat percentages were significantly associated with an increased risk of non-alcoholic fatty liver disease, with total fat percentage yielding an AUC of 0.932 in men and 0.917 in women.
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