Why the study?
The BP level at which treatment is no longer efficacious remains uncertain, and observational data show potential risk even at normal or optimal BP ranges.
Design
Editorial
Key result
Mendelian Randomization and observational studies suggest a linear relationship between systolic and diastolic blood pressure and cardiovascular events, even at levels considered normal or optimal.
Authors
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Does not yet support treating below current thresholds; leaves open need for RCTs targeting optimal-range BP.
This article discusses the evolving definition of hypertension and the role of observational and Mendelian Randomization studies in understanding the linear relationship between blood pressure and cardiovascular risk.
McCarthy et al. (2023) conducted an editorial in Hypertension and Cardiovascular Risk. Systolic and diastolic blood pressure was evaluated. Mendelian Randomization and observational studies suggest a linear relationship between systolic and diastolic blood pressure and cardiovascular events, even at levels considered normal or optimal.
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