Key result
High serum lactate during OHCA CPR shows no association with worse short-term survival.
Why the study?
The prognostic role of lactate in out-of-hospital cardiac arrest remains unclear.
Does serum lactate level predict return of spontaneous circulation and short-term survival in patients with out-of-hospital cardiac arrest?
Population
105 patients aged ≥18 years experiencing OHCA after arrival at hospital
Comparison
Low serum lactate (≤9.9 mmol/l) vs high serum lactate (≥10 mmol/l)
Design
13-month prospective observational cohort study
Authors
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Lower lactate may link to more VF in OHCA; leaves open survival prediction and needs prospective validation before use.
Cohort (n=105)
Does serum lactate level predict return of spontaneous circulation and short-term survival in patients with out-of-hospital cardiac arrest?
Absolute Event Rate: 23.5% vs 40%
p-value: p=0.32
Lower serum lactate levels during CPR for out-of-hospital cardiac arrest may be associated with better short-term outcomes, though statistical significance for survival was not reached.
Charlton et al. (2022) conducted a cohort in Out-of-hospital cardiac arrest (OHCA) (n=105). High serum lactate (≥10 mmol/l) vs. Low serum lactate (≤9.9 mmol/l) was evaluated on Short-term survival (>24 hours) (p=0.32). High serum lactate (≥10 mmol/l) during CPR for OHCA was not significantly associated with worse short-term survival compared to low lactate (23.5% vs 40%; P=0.32).
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