Key result
Chronic kidney disease was independently associated with progressively higher risks of major bleeding and mortality in patients with atrial fibrillation, but not thromboembolism.
Why the study?
CKD is highly prevalent in AF, but the association between CKD and adverse clinical consequences in this population remains under debate.
Does chronic kidney disease increase the risk of adverse clinical events in patients with atrial fibrillation?
Observational
Does chronic kidney disease increase the risk of adverse clinical events in patients with atrial fibrillation?
Answers are grounded in this paper and cite their sources.
In patients with atrial fibrillation, chronic kidney disease is an independent predictor of major bleeding and mortality, but not thromboembolism.
BACKGROUND: Chronic kidney disease (CKD) is highly prevalent in patients with atrial fibrillation (AF). However, the association between CKD and clinical consequences in AF patients is still under debate. METHODS: ) groups. The risks of thromboembolism, major bleeding, and cardiovascular mortality were estimated with Fine-Gray regression analysis according to CKD status. Cox regression was performed to assess the risk of all-cause mortality associated with CKD. Risk of all-cause mortality also increased among patients with moderate or severe CKD. CONCLUSIONS: CKD status was independently associated with progressively higher risks of major bleeding and mortality, but didn't seem to be an independent predictor of thromboembolism in AF patients.
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Li et al. (2021) conducted an observational in Atrial fibrillation. Chronic kidney disease (CKD) vs. No CKD or lower severity CKD was evaluated on Thromboembolism, major bleeding, cardiovascular mortality, and all-cause mortality (p=< 0.0001). Chronic kidney disease was independently associated with progressively higher risks of major bleeding and mortality in patients with atrial fibrillation, but not thromboembolism.
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