Key result
TAVs yield ~39% longer leaflet blood residence time versus surgical bioprostheses in computational models.
Why the study?
Does geometric confinement of a transcatheter aortic valve increase blood residence time on the leaflets compared to a surgical bioprosthesis?
Population
Two computational models representing a surgical bioprosthesis and a transcatheter aortic valve (TAV)
Comparison
Transcatheter aortic valve model with geometric… vs Surgical bioprosthesis model
Design
Preclinical
Authors
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Prolonged leaflet residence time may predispose to TAV thrombosis; leaves open whether design changes alter clinical outcomes.
Does geometric confinement of a transcatheter aortic valve increase blood residence time on the leaflets compared to a surgical bioprosthesis?
p-value: p=< 0.0001
Computational modeling demonstrates that geometric confinement of transcatheter aortic valves increases blood residence time on the leaflets, which may act as a permissive factor for valve thrombosis.
Vahidkhah et al. (2016) studied Valve thrombosis following transcatheter aortic valve replacement. Transcatheter aortic valve (TAV) model vs. Surgical bioprosthesis model was evaluated on Blood residence time (BRT) on the leaflets (p=< 0.0001). In computational models, transcatheter aortic valves exhibited significantly longer blood residence time on the leaflets compared to surgical bioprostheses during forward flow (39% higher, P<0.0001).
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