Key result
Epidural volume extension with saline prolongs postoperative analgesia by ~100 minutes versus control.
Why the study?
Epidural volume extension aims to mitigate spinal anaesthesia-induced hypotension by reducing local anaesthetic doses, but its effects on sensory-motor block characteristics and postoperative analgesia in proximal femoral nailing required evaluation.
Does epidural volume extension improve the duration of postoperative analgesia in adult patients undergoing proximal femoral nailing?
Population
105 adult patients scheduled to undergo proximal femoral nailing
Comparison
Intrathecal hyperbaric bupivacaine plus 10 mL or 20 mL epidural normal saline vs control
Design
Prospective, double-blind randomized controlled trial
Authors
Loading...
EVE prolongs postoperative analgesia after PFN; extends RCT evidence supporting its use to optimize spinal anesthesia in lower-limb orthopedic surgery.
RCT (n=105)
Double-blind
Computer-generated random numbers in opaque sealed envelopes
No
Does epidural volume extension improve the duration of postoperative analgesia in adult patients undergoing proximal femoral nailing?
Absolute Event Rate: 365.09% vs 265.77%
p-value: p=<0.01
Epidural volume extension with normal saline significantly prolongs postoperative analgesia and shortens the onset of sensory-motor block in patients undergoing proximal femoral nailing.
Bedi et al. (2023) conducted an RCT in Proximal femoral fractures requiring proximal femoral nailing (n=105). Epidural volume extension with normal saline vs. Intrathecal hyperbaric bupivacaine alone was evaluated on Duration of postoperative analgesia (p=<0.01). Epidural volume extension with 10 mL or 20 mL of normal saline significantly prolonged the duration of postoperative analgesia compared to control (365.09 and 330.06 vs 265.77 min, P < 0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: