Key result
Current pulses in rabbit ventricular cells trigger direct 1:1 to 2:1 rhythm transitions and bistability.
Why the study?
The mechanisms underlying the direct transition from 1:1 to 2:1 rhythm and the presence of hysteresis and bistability in single ventricular cells under periodic stimulation were unclear.
Population
Single quiescent cells isolated from rabbit ventricular muscle
Comparison
Different pulse amplitudes and basic cycle lengths (BCL) during periodic current pulse stimulation
Design
Experimental whole-cell recording with numerical ionic model simulations
Authors
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Hypothesis-generating for arrhythmia mechanisms like Mobitz II block; requires intact-heart and clinical validation before any practice implications.
This preclinical study demonstrates hysteresis and bistability in the transition from 1:1 to 2:1 rhythms in ventricular cells, providing mechanistic insights into cardiac arrhythmias such as Mobitz type II block and ischemic alternans.
Yehia et al. (1999) studied this question. Periodic train of current pulses was evaluated on Transition from 1:1 to 2:1 rhythm, hysteresis, and bistability. Periodic current pulses in a single rabbit ventricular cell demonstrated a direct transition from 1:1 to 2:1 rhythm, hysteresis, and bistability, supported by ionic model simulations.
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