Key result
Electrical alternans was found in all recordings within the ischaemic area and two-thirds of the border area, but not in non-ischaemic areas, peaking at 2-7 min and 15-40 min post-ischaemia.
Population
16 anaesthetized and ventilated Landrace pigs
Comparison
Acute regional ischaemia induced by ligation of… vs Non-ischaemic myocardium areas
Design
Preclinical
Follow-up
1 hour
Authors
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Electrical alternans marks ischaemic zones in animal models; hypothesis-generating for causal links to ventricular arrhythmias.
Electrical alternans is a distinctive electrophysiological characteristic of acute ischaemic myocardium that may be causally related to ventricular arrhythmias.
Dilly et al. (1988) studied Acute regional ischaemia (n=16). Left coronary artery ligation (acute regional ischaemia) vs. Non-ischaemic areas was evaluated on Electrical alternans and restitution curves. Electrical alternans was found in all recordings within the ischaemic area and two-thirds of the border area, but not in non-ischaemic areas, peaking at 2-7 min and 15-40 min post-ischaemia.