November 15, 1994The Journal of PhysiologyOpen Access

Regional alternans in relaxation and the onset of pulsus alternans in the heart of the anaesthetized pig.

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Population

12 anaesthetized pigs with chest wall removed

Design

Preclinical

Authors

CMConrad MurphyCharing Cross Hospital MLMax J. LabElectrophysiology SHS M HornerWhitchurch Hospital

Discussion

Member takes

Implication

Challenges assumption of primary relaxation abnormality in pulsus alternans; hypothesis-generating for regional contractility mechanisms.

Structured PICO

Population

12 anaesthetized pigs with chest wall removed

Intervention

Right atrial pacing at cycle lengths 50-150 ms greater than the threshold for pulsus alternans

Outcome

Regional and global contraction patterns (alternans in maximum rate of ventricular pressure decay and end-diastolic length)surrogate

Alternans in global measures of relaxation may simply be a manifestation of regional alternans in contractility, challenging the assumption that relaxation is the primary abnormality in pulsus alternans.

Cite This Study

Murphy et al. (1994) studied this question.

synapsesocial.com/papers/6a711de8ac440176ef29cd5b https://doi.org/10.1113/jphysiol.1994.sp020431

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