September 1, 1967CirculationOpen Access

Mechanisms of Pulsus Alternans

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Population

32 patients total: 3 patients studied by cineangiography and 29 patients with valvular aortic stenosis who…

Design

Case_series

Authors

KCKeith CohnUnited States Department of Veterans Affairs HSH. SandlerAmes Research Center EHE. William HancockElectrophysiology

Discussion

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Implication

Pulsus alternans may decouple from LVEDP/EDV changes; Level 5 data leaves open preload-independent mechanisms in LV disease and aortic stenosis.

Structured PICO

Population

32 patients total: 3 patients studied by cineangiography (2 with left ventricular disease, 1 with normal left ventricular function) and 29 patients with valvular aortic stenosis who showed pulsus alternans during left heart catheterization.

Intervention

Cineangiographic determinations of left ventricular volume and left heart catheterization (observational)

Outcome

Variations in left ventricular end-diastolic pressure (LVEDP), end-diastolic volume (EDV), cardiac cycle length, and diastolic intervalsurrogate

Pulsus alternans can occur without detectable variations in left ventricular end-diastolic pressure or volume, though transient alternations often follow extrasystoles.

Cite This Study

Cohn et al. (1967) studied this question.

synapsesocial.com/papers/6a73a39999c817e23aa7350a https://doi.org/10.1161/01.cir.36.3.372

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Implication

Pulsus alternans may decouple from LVEDP/EDV changes; Level 5 data leaves open preload-independent mechanisms in LV disease and aortic stenosis.

Mechanisms of Pulsus Alternans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of Pulsus Alternans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider