Population
7 isolated, perfused canine left ventricles ejecting into a simulated arterial impedance
Comparison
Measurement of left ventricular pressure-volume… vs Comparison between strong and weak beats
Design
Preclinical
Authors
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Provides mechanistic insight into pulsus alternans; leaves open translation from animal models to human therapy.
The study demonstrates that pulsus alternans is characterized by alternating ventricular chamber contractility that is not solely due to the Starling mechanism.
McGaughey et al. (1985) studied this question.
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