Spiramycin Excretion in Animals: II. Repeated Oral Doses in Rats

After 7 to 14 spiramycin doses, plasma and selected tissues were assayed for residual antibiotic. Plasma contained detectable spiramycin only in samples taken 24 hours after the last 400 mg/kg dose. After 100 to 400 mg/kg levels, spiramycin remained in mandibular gingiva and bone at least seven days. Parotid and submaxillary glands contained antibiotic 24 hours after 25 to 400 mg/kg doses and 14 to 21 days after 400 mg/kg doses.