P5142Survival and left ventricular function changes in fulminant versus non-fulminant acute myocarditis

Background: Previous reports have suggested that despite their dramatic presentation, patients with fulminant myocarditis (FM) might have better outcome than those with acute non-fulminant myocarditis (NFM). Purpose: In this retrospective study, we report outcome and changes in left ventricular ejection fraction (LVEF) in a large cohort of patients with FM and NFM. Methods: The study population consists of 187 consecutive patients admitted between May 2001 and November 2016 in 2 tertiary hospitals with a diagnosis of acute myocarditis (onset of symptoms <1 month) of whom 55 (median age 33 years, Q1-Q3: 17–42 years) required inotropes and/or mechanical circulatory support (FM) whilst the remaining 132 patients (median age 33 years, Q1-Q2: 23–40 years) were hemodynamically stable (NFM). We also performed a sub-analysis in 130 adult patients with acute viral myocarditis and viral prodrome within 2 weeks from the onset which included 34 viral FM (v-FM) vs. 96 viral NFM (v-NFM). Patients with giant-cell, eosinophilic myocarditis or cardiac sarcoidosis and subjects <15 years of age were excluded from the latter sub-analysis.