Synthesis of 3‐substituted‐4‐phenyl‐2‐thioxo‐1,2,3,4,5,6,7,8‐octahydrobenzo[4,5]thieno[2,3‐á]pyrimidines

The reactions between 3‐benzoyl‐2‐isothiocyanato‐4,5,6,7‐tetrahydrobenzo[b]thiophene and hydrazine or primary amines have been studied. The products obtained were identified as derivatives of 4‐phenyl‐2‐thioxo‐2,3,5,6,7,8‐hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine. Their easy reduction with sodium borohydride provided a useful method for the synthesis of 3‐substituted‐4‐phenyl‐2‐thioxo‐1,2,3,4,5,6,7,8‐octahydrobenzo[4,5]thieno[2,3‐d]pyrimidines. Both kind of compounds were evaluated as potential analgesic, anti‐inflammatory and anti‐arthritic agents.