Key result
Proposed technique visualizes cardiac collagen turnover via MMP-1 and MMP-8 activity to elucidate SCD causes.
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Analyzing MMP-1 and MMP-8 activity to visualize collagen turnover may help elucidate the postmortem etiology of sudden cardiac death.
Sudden cardiac death is natural, unexpected death, related to cardiovascular disease. Its postmortem elucidation is significant, as the family of the deceased aspires to prevent other sudden deaths. Irrespective of the proper etiological entity, the myocardial collagen matrix remodels, associated with the progression of cardiovascular diseases. It has become evident that many mediators such as humoral factors, transforming growth factor (TGF)-β1 among them, are involved in the remodeling process. Cardiac remodeling is the balance of regenerative and eliminatory processes that include enzymes involved in the degradation of extracellular matrix (ECM) components. Enzymes capable of degrading native fibrillar collagen are interstitial collagenases, specifically matrix metalloproteinases (MMP)-1 and MMP-8. Here, we suggest a technique of visualizing turnover of collagen in cardiac tissue.
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Šoša et al. (2016) studied Sudden cardiac death. Visualizing turnover of collagen in cardiac tissue was evaluated. A technique for visualizing collagen turnover in cardiac tissue via matrix metalloproteinases (MMP)-1 and MMP-8 activity is proposed to help elucidate the cause of sudden cardiac death.
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