Key result
Cysteine cathepsins and matrix metalloproteinases play an important role in extracellular matrix remodeling during cardiac hypertrophy.
This review summarizes the role of cysteine cathepsins and MMPs in cardiac remodeling, highlighting them as potential therapeutic targets for cardiac hypertrophy.
Answers are grounded in this paper and cite their sources.
Implicates cathepsins and MMPs in hypertrophy remodeling; leaves open whether inhibition improves clinical outcomes.
Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeutic targets. One of the hallmarks of CH is the remodeling of the extracellular matrix (ECM). Multiple studies have shown an important role of cysteine proteases and matrix metalloproteinases (MMPs) in the remodeled heart. This review focuses on the role of cysteine cathepins and MMPs in cardiac remodeling.
No takes yet. Share an insight, caveat, or question.
Riaz et al. (2017) conducted a review in Cardiac hypertrophy and remodeling. Cysteine cathepsins and matrix metalloproteinases (MMPs) was evaluated. Cysteine cathepsins and matrix metalloproteinases play an important role in extracellular matrix remodeling during cardiac hypertrophy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: