Key result
Synthetic Asp 1 consistently induces tachyphylaxis in rats at higher doses, unlike Aspg 1.
Why the study?
Does aspartyl 1 angiotensin II induce tachyphylaxis compared to asparginyl 1 angiotensin II in rats?
Population
Normal and nephrectomized rats
Comparison
Synthetic aspartyl 1 angiotensin II administered… vs Synthetic asparginyl 1 angiotensin II…
Design
Preclinical
Authors
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Animal data support Asp1 as natural angiotensin; leaves open N-terminal role in human pressor responses.
Does aspartyl 1 angiotensin II induce tachyphylaxis compared to asparginyl 1 angiotensin II in rats?
Aspartyl 1 angiotensin II, unlike asparginyl 1 angiotensin II, induces tachyphylaxis in rats, indicating that the N-terminal amino acid is crucial for pressor responsiveness and supporting Asp 1 as the natural form of angiotensin released in vivo.
Sambhi et al. (1967) studied Normal and nephrectomized rats. Synthetic aspartyl 1 angiotensin II (Asp 1) vs. Asparginyl 1 angiotensin II (Aspg 1) was evaluated on Pressor responses and development of tachyphylaxis. Synthetic aspartyl 1 angiotensin II (Asp 1) consistently induced tachyphylaxis in rats at greater than minimal doses, whereas asparginyl 1 angiotensin II (Aspg 1) did not at any dose level.
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