Key result
Fractional excretion of atrial natriuretic peptide significantly correlated with creatinine clearance (r=-0.530, p<0.01), indicating increased fractional excretion with declining renal function.
Why the study?
Regulation of renal excretion of atrial natriuretic peptide (ANP) in kidney disease patients and healthy persons was not fully understood.
Cross-Sectional (n=63)
No
Fractional excretion of ANP increases with decreasing renal function, while plasma ANP concentration does not correlate with creatinine clearance in patients without volume overload.
Caution advised interpreting ANP in renal impairment; leaves open its diagnostic role in CKD.
Regulation of renal excretion of atrial natriuretic peptide (ANP) was studied in kidney disease patients and healthy kidney donors. The measured ANP concentration in the patient's plasma did not correlate with their creatinine clearance (Ccr), while the fractional excretion of ANP (FEANP) significantly correlated with Ccr. FEANP in healthy persons is less than 1%. In the healthy donors of kidneys for transplantation, approximately 80% of the plasma ANP from the renal artery appeared in the renal vein. From these results, this high recovery of ANP in the veins does not appear to be adequately explained by its degradation in the renal arterioles and nephrons. The FEANP from kidney disease patients significantly correlated with FENa, FEK and FEP, but not with FECa and FEMg. The manner of ANP handling in the nephron may possibly differ from that of Ca or Mg.
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Marumo et al. (1988) conducted a cross-sectional in Kidney disease (n=63). Impaired renal function (kidney disease) vs. Normal renal function (healthy donors) was evaluated on Correlation between fractional excretion of ANP (FEANP) and creatinine clearance (Ccr) (r=-0.530, p=<0.01). Fractional excretion of atrial natriuretic peptide significantly correlated with creatinine clearance (r=-0.530, p<0.01), indicating increased fractional excretion with declining renal function.
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