Induction of Intestinal Mastocytosis in Nude Mice by Repeated Injection of Interleukin-3

This is the authors' abstract. We don't add key points for this paper.

The number of mast cells in various tissues of nude mice was examined after daily injection of Interleukin-3 (IL-3), which was purified from the media conditioned by WEHI-3B cell line. Repeated intraperitoneal injection of IL-3 caused a significant increase in the number of mucosal mast cells (MMC) in the epithelium of small intestine more than 30-fold and also to a lesser extent in the villous lamina propria of small intestine and caecum. The number of mast cells in the spleen, approximately 60% of which were formalin-resistant and were assumed as connective tissue type mast cells (CTMC), increased 3-fold by IL-3 treatment. Although statistically not significant, the number of mast cells in the ear skin also slightly increased.